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| Modelo | Desplazamiento | Cil/Vál | kW/CV | Fuel | Producido | ||
| S 350 | 3724 | 3724 Gasolina |
6 / 3 | 180 / 245 | 245 | Gasolina | 2005 - 2006 |
| S 400 Hybrid | 3498 | 3498 Gasolina/eléctrico |
6 / 4 | 220 / 299 | 299 | Gasolina/eléctrico | 2009 - 2013 |
| S 400 4-matic | 4663 | 4663 Gasolina |
8 / 4 | 250 / 340 | 340 | Gasolina | 2008 - 2009 |
| S 430 | 4266 | 4266 Gasolina |
8 / 3 | 205 / 279 | 279 | Gasolina | 2005 - 2006 |
| S 450 (221.070, 221.170) | 4663 | 4663 Gasolina |
8 / 4 | 250 / 340 | 340 | Gasolina | 2005 - a.m. |
| S 450 4-matic (221.084, 221.184) | 4663 | 4663 Gasolina |
8 / 4 | 250 / 340 | 340 | Gasolina | 2005 - a.m. |
| S 550 (221.073, 221.173) | 4663 | 4663 Gasolina |
8 / 4 | 320 / 435 | 435 | Gasolina | 2011 - a.m. |
| S 500 CGI (221.073, 221.173) | 4663 | 4663 Gasolina |
8 / 4 | 320 / 435 | 435 | Gasolina | 2011 - a.m. |
| S 550 (221.094, 221.194) | 4663 | 4663 Gasolina |
8 / 4 | 320 / 435 | 435 | Gasolina | 2011 - a.m. |
| S 500 CGI 4-matic (221.094, 221.194) | 4663 | 4663 Gasolina |
8 / 4 | 320 / 435 | 435 | Gasolina | 2011 - a.m. |
| S 550 (221.071, 221.171) | 5461 | 5461 Gasolina |
8 / 4 | 285 / 388 | 388 | Gasolina | 2005 - a.m. |
| S 500 (221.071, 221.171) | 5461 | 5461 Gasolina |
8 / 4 | 285 / 388 | 388 | Gasolina | 2005 - a.m. |
| S 550 (221.086, 221.186) | 5461 | 5461 Gasolina |
8 / 4 | 285 / 388 | 388 | Gasolina | 2005 - a.m. |
| S 500 4-matic (221.086, 221.186) | 5461 | 5461 Gasolina |
8 / 4 | 285 / 388 | 388 | Gasolina | 2005 - a.m. |
| S 600 | 5513 | 5513 Gasolina |
12 / 3 | 368 / 500 | 500 | Gasolina | 2005 - 2007 |
| S 600 (221.176) | 5513 | 5513 Gasolina |
12 / 3 | 380 / 517 | 517 | Gasolina | 2005 - a.m. |
| S 55 AMG | 5439 | 5439 Gasolina |
8 / 3 | 349 / 475 | 475 | Gasolina | 2005 - 2006 |
| S 63 AMG (221.077, 221.177) | 6208 | 6208 Gasolina |
8 / 4 | 386 / 525 | 525 | Gasolina | 2006 - a.m. |
| S 63 AMG (221.074, 221.174) | 5461 | 5461 Gasolina |
8 / 4 | 400 / 544 | 544 | Gasolina | 2011 - a.m. |
| S 65 AMG (221.179) | 5980 | 5980 Gasolina |
12 / 3 | 450 / 612 | 612 | Gasolina | 2005 - a.m. |
| S 65 AMG (221.179) | 5980 | 5980 Gasolina |
12 / 3 | 463 / 630 | 630 | Gasolina | 2011 - a.m. |
| S 350 CDI 4-matic | 2987 | 2987 Gasóleo |
6 / 4 | 179 / 243 | 243 | Gasóleo | 2011 - a.m. |