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| Modelo | Desplazamiento | Cil/Vál | kW/CV | Fuel | Producido | ||
| CLS 350 (219.357) | 3498 | 3498 Gasolina |
6 / 4 | 215 / 292 | 292 | Gasolina | 2006 - 2010 |
| CLS 350 | 3498 | 3498 Gasolina |
6 / 4 | 228 / 310 | 310 | Gasolina | 2009 - a.m. |
| CLS 350 CGI (219.357) | 3498 | 3498 Gasolina |
6 / 4 | 215 / 292 | 292 | Gasolina | 2009 - 2010 |
| CLS 550 (219.372) | 5461 | 5461 Gasolina |
8 / 4 | 285 / 388 | 388 | Gasolina | 2006 - 2010 |
| CLS 500 (219.372) | 5461 | 5461 Gasolina |
8 / 4 | 285 / 388 | 388 | Gasolina | 2006 - 2010 |
| CLS 500 | 4966 | 4966 Gasolina |
8 / 3 | 218 / 296 | 296 | Gasolina | 2005 - 2006 |
| CLS 500 | 5461 | 5461 Gasolina |
8 / 4 | 285 / 388 | 388 | Gasolina | 2006 - a.m. |
| CLS 550 | 5461 | 5461 Gasolina |
8 / 4 | 285 / 388 | 388 | Gasolina | 2006 - a.m. |
| CLS 55 AMG (219.376) | 5439 | 5439 Gasolina |
8 / 3 | 350 / 476 | 476 | Gasolina | 2005 - 2010 |
| CLS 63 AMG (219.377) | 6208 | 6208 Gasolina |
8 / 4 | 378 / 514 | 514 | Gasolina | 2006 - 2010 |