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| Modelo | Desplazamiento | Cil/Vál | kW/CV | Fuel | Producido | ||
| S 500 Hybrid / e (222.163) | 2996 | 2996 Gasolina/eléctrico |
6 / 4 | 245 / 333 | 333 | Gasolina/eléctrico | 2014 - a.m. |
| S 550 (222.082, 222.182) | 4663 | 4663 Gasolina |
8 / 4 | 335 / 455 | 455 | Gasolina | 2013 - a.m. |
| S 500 (222.082, 222.182) | 4663 | 4663 Gasolina |
8 / 4 | 335 / 455 | 455 | Gasolina | 2013 - a.m. |
| S 550 (222.085, 222.185) | 4663 | 4663 Gasolina |
8 / 4 | 335 / 455 | 455 | Gasolina | 2013 - a.m. |
| S 500 4-matic (222.085, 222.185) | 4663 | 4663 Gasolina |
8 / 4 | 335 / 455 | 455 | Gasolina | 2013 - a.m. |
| S 600 (222.176) | 5980 | 5980 Gasolina |
12 / 3 | 390 / 530 | 530 | Gasolina | 2014 - a.m. |
| S 63 AMG 4-matic (222.178) | 5461 | 5461 Gasolina |
8 / 4 | 430 / 585 | 585 | Gasolina | 2013 - a.m. |
| S 65 L AMG (222.179) | 5980 | 5980 Gasolina |
12 / 3 | 463 / 630 | 630 | Gasolina | 2014 - a.m. |
| S 65 AMG (222.179) | 5980 | 5980 Gasolina |
12 / 3 | 463 / 630 | 630 | Gasolina | 2014 - a.m. |